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TRUTUMOR TUMOR PRESERVATION, PERTURBATION, AND PROFILING

Farcast's TruTumor technology maintains the equilibrium between stromal, tumor and immune components while uniquely retaining the spatial contexture of the original tumor microenvironment. Such living, near native, heterogeneous tumor replicas are ideal for determining true treatment impact and comparing responses of different treatments on the same TME.

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Farcast's technology comprehensively combines multimodal data from every tumor sample processed. Utilization of such true perturbation based datasets leads to a more precise identification of causal processes.

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Histopathology

Morphological assessment of mechanistic response of drug to assess proliferation, cell death and immune cell infiltration induced by treatment

Hispathology

Gene Expression

Measurement of differential gene expression resulting from therapeutic intervention

 

Patient cohort stratification discovery with baseline gene expression

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Farcast proprietary images

PanCK

Fox P3

CD8

Spatial Biology

Live imaging that offers a comprehensive evaluation of true tumor microenvironment

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Multiplex immunofluorescence techniques that help visualization of the spatial distribution of different sub-population of immune and cancer cells in the original human tumor microenvironment

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Assessment of changes in spatial biology caused by therapeutic intervention in the treated tumor microenvironment

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Flowcytometry

Precise measurement and characterization of diverse immune cell populations within the tumor microenvironment

 

Customized panels for assessment of specific immune cell type activity indicative of therapy response

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Cytokine Profiling

Flexible, multiplexed quantitative evaluation of cytokines/chemokines released due to therapeutic intervention 

 

Immune effector cells for assessing early response in tumor fragments in response to drug exposure

Kinetic Assays

Discrete time course measurements to understand the metabolic state and viability of explants in the culture system for up to 72 hours

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