
TRUTUMOR TUMOR PRESERVATION, PERTURBATION, AND PROFILING
Farcast's TruTumor technology maintains the equilibrium between stromal, tumor and immune components while uniquely retaining the spatial contexture of the original tumor microenvironment. Such living, near native, heterogeneous tumor replicas are ideal for determining true treatment impact and comparing responses of different treatments on the same TME.
Farcast's technology comprehensively combines multimodal data from every tumor sample processed. Utilization of such true perturbation based datasets leads to a more precise identification of causal processes.



Histopathology
Morphological assessment of mechanistic response of drug to assess proliferation, cell death and immune cell infiltration induced by treatment
Gene Expression
Measurement of differential gene expression resulting from therapeutic intervention
Patient cohort stratification discovery with baseline gene expression

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Farcast proprietary images
PanCK
Fox P3
CD8
Spatial Biology
Live imaging that offers a comprehensive evaluation of true tumor microenvironment
Multiplex immunofluorescence techniques that help visualization of the spatial distribution of different sub-population of immune and cancer cells in the original human tumor microenvironment
Assessment of changes in spatial biology caused by therapeutic intervention in the treated tumor microenvironment
Flowcytometry
Precise measurement and characterization of diverse immune cell populations within the tumor microenvironment
Customized panels for assessment of specific immune cell type activity indicative of therapy response



Cytokine Profiling
Flexible, multiplexed quantitative evaluation of cytokines/chemokines released due to therapeutic intervention
Immune effector cells for assessing early response in tumor fragments in response to drug exposure
Kinetic Assays
Discrete time course measurements to understand the metabolic state and viability of explants in the culture system for up to 72 hours


