HISTOPATHOLOGY
Morphological assessment of mechanistic response of drug to assess proliferation, cell death and immune cell infiltration induced by treatment
GENE EXPRESSION
Measurement of differential gene expression across treatment arms in tumor, stromal and immune compartments using NanoString
Pan cancer and immune panels for comprehensive analysis of gene signatures and cell scores indicative of drug response
Farcast proprietary images, generated with human tumor tissues
Live
Dead
HIGH CONTENT IMAGING
Comprehensive evaluation of live-dead cells and immune cells in a Tumor immune MicroEnvironment
Quantitative live cell imaging for objective assessment of tumoricidal and immune response to drug modulation
FLOWCYTOMETRY
Precise measurement and characterization of diverse immune cell populations within the explant system
Customized gating strategies for assessment of specific immune cell type activity indicative of drug response
CYTOKINE PROFILING
Multiplexed quantitative evaluation of cytokines/ chemokine release using Luminex.
Immune effector cells early response in tumor explants in response to drug exposure.
KINETIC ASSAYS
Discrete time course measurements to understand metabolic state and viability of explants in the culture system
